Blar i forfatter "Laugsand, Lars Erik"

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    • Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study 

      Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål; Åsvold, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-06)
      <p><i>Background</i>: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals.</p> <p><i>Methods</i>: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control ...

    • Repositioning of the global epicentre of non-optimal cholesterol 

      Taddei, Cristina; Zhou, Bin; Bixby, Honor; Carrillo-Larco, Rodrigo M.; Danaei, Goodarz; Jackson, Rod T.; Ahmed, Soheir H; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bjertness, Espen; Bjertness, Marius Bergsmark; Graff-Iversen, Sidsel; Haugsgjerd, Teresa Risan; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meyer, Haakon E; Sen, Abhijit; Tell, Grete S.; Vatten, Lars Johan; Wilsgaard, Tom; Farzadfar, Farshad; Sophiea, Marisa K.; Di Cesare, Mariachiara; Iurilli, Maria L. C.; Martinez, Andrea Rodriguez; Asghari, Golaleh; Dhana, Klodian; Gulayin, Pablo; Kakarmath, Sujay; Santero, Marilina; Voortman, Trudy; Riley, Leanne M.; Cowan, Melanie J.; Savin, Stefan; Bennett, James E.; Stevens, Gretchen A.; Paciorek, Christopher J.; Aekplakorn, Wichai; Cifkova, Renata; Giampaoli, Simona; Kengne, Andre Pascal; Khang, Young-Ho; Kuulasmaa, Kari; Laxmaiah, Avula; Margozzini, Paula; Mathur, Prashant (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-03)
      High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which ...

    • Rising rural body-mass index is the main driver of the global obesity epidemic in adults 

      Bixby, Honor; Bentham, James; Zhou, Bin; Di Cesare, Mariachiara; Paciorek, Christopher J.; Bennett, James E.; Taddei, Cristina; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Carrillo-Larco, Rodrigo M.; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ekelund, Ulf; Kolle, Elin; Steene-Johannessen, Jostein; Tarp, Jakob; Ariansen, Inger; Biehl, Anna Månsson; Graff-Iversen, Sidsel; Meisfjord, Jørgen Rajan; Bjertness, Espen; Bjertness, Marius Bergsmark; Meyer, Haakon E; Haugsgjerd, Teresa Risan; Tell, Grethe S.; Janszky, Imre; Krokstad, Steinar; Laugsand, Lars Erik; Sen, Abhijit; Vatten, Lars Johan; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Khang, Young-Ho; Soric, Maroje; Gregg, Edward W.; Miranda, J. Jaime; Bhutta, Zulfiqar A.; Savin, Stefan; Sophiea, Marisa K.; Iurilli, Maria L. C.; Solomon, Bethlehem D.; Cowan, Melanie J.; Riley, Leanne M.; Danaei, Goodarz; Bovet, Pascal; Chirita-Emandi, Adela; Hambleton, Ian R; Hayes, Alison J; Ikeda, Nayu; Kengne, Andre P; Laxmaiah, Avula (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-08)
      Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, ...

    • Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition 

      Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey; Åsvold, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-15)
      PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce serum LDL (low-density lipoprotein) cholesterol (LDL-C) by increasing uptake in the liver. Although some long-term trials have evaluated their safety, broad investigations of outcomes over the lifetime, leveraging genetic variation in serum PCSK9, have seldomly been conducted. We investigated effects of these variants on a range ...

    • Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants 

      Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Danaei, Goodarz; Cowan, Melanie J.; Paciorek, Christopher J.; Singh, Gitanjali M; Hajifathalian, Kaveh; Bennett, James E.; Taddei, Cristina; Bilano, Ver; Carrillo-Larco, Rodrigo M.; Djalalinia, Shirin; Khatibzadeh, Shahab; Lugero, Charles; Peykari, Niloofar; Zhang, Wan Zhu; Lu, Yuan; Stevens, Gretchen A.; Riley, Leanne M.; Bovet, Pascal; Elliott, Paul; Gu, Dongfeng; Ikeda, Nayu; Jackson, Rod T; Joffres, Michel; Kengne, André Pascal; Laatikainen, Tiina; Lam, Tai Hing; Laxmaiah, Avula; Liu, Jing; Miranda, J. Jaime; Mondo, Charles K; Neuhauser, Hannelore K; Sundström, Johan; Smeeth, Liam; Sorić, Maroje; Woodward, Mark; Ezzati, Majid; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Abdul Rahim, Hanan; Abu-Rmeileh, Niveen M.; Acosta-Cazares, Benjamin; Adams, Robert; Aekplakorn, Wichai; Afsana, Kaosar; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmadvand, Alireza; Ahrens, Wolfgang; Al Raddadi, Rajaa; Al Woyatan, Rihab; Ali, Mohamed M; Alkerwi, Ala'a; Aly, Eman; Amuzu, Antoinette; Amouyel, Philippe; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ängquist, Lars; Anjana, Ranjit Mohan; Ansong, Daniel; Aounallah-Skhiri, Hajer; Araújo, Joana; Ariansen, Inger Kristine; Aris, Tahir; Arlappa, Nimmathota; Aryal, Krishna; Arveiler, Dominique; Assah, Felix K.; Assunção, Maria Cecília; Avdicová, Mária; Azevedo, Ana; Azizi, Fereidoun; Babu, Bontha V; Bahijri, Suhad; Balakrishna, Nagalla; Bandosz, Piotr; Banegas, Jose R; Barbagallo, Carlo M.; Barcelo, Alberto; Barkat, Amina; Barros, Aluisio J.D.; Barros, Mauro V; Bata, Iqbal; Batieha, Anwar M.; Baur, Louise A.; Beaglehole, Robert; Ben Romdhane, Habiba; Benet, Mikhail; Benson, Lowell S.; Bernabe-Ortiz, Antonio; Bernotiene, Gailute; Bettiol, Heloisa; Bhagyalaxmi, Aroor; Bharadwaj, Sumit; Bhargava, Santosh K.; Bi, Yufang; Bikbov, Mukharram; Bjerregaard, Peter; Bjertness, Espen; Ekelund, Ulf; Graff-Iversen, Sidsel; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Laugsand, Lars Erik; Mathiesen, Ellisiv B.; Sen, Abhijit; Steene-Johannessen, Jostein; Vatten, Lars Johan; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-15)
      Background:<br>Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defi ned as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher.<br> Methods:<br>For ...

    • Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults 

      Bentham, James; Di Cesare, Mariachiara; Bilano, Ver; Bixby, Honor; Zhou, Bin; Stevens, Gretchen A.; Riley, Leanne M.; Taddei, Cristina; Hajifathalian, Kaveh; Lu, Yuan; Savin, Stefan; Cowan, Melanie J.; Paciorek, Christopher J.; Chirita-Emandi, Adela; Hayes, Alison J; Katz, Joanne; Kelishadi, Roya; Kengne, André Pascal; Khang, Young-Ho; Laxmaiah, Avula; Li, Yanping; Ma, Jun; Miranda, J. Jaime; Mostafa, Aya; Neovius, Martin; Padez, Cristina; Rampal, Lekhraj; Zhu, Aubrianna; Bennett, James E.; Danaei, Goodarz; Bhutta, Zulfiqar A.; Ezzati, Majid; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Hamid, Zargar Abdul; Abu-Rmeileh, Niveen M.; Acosta-Cazares, Benjamin; Acuin, Cecilia; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmadvand, Alireza; Ahrens, Wolfgang; Ajlouni, Kamel; Akhtaeva, Nazgul; Al-Hazzaa, Hazzaa M.; Al-Othman, Amani Rashed; Al-Raddadi, Rajaa; AlBuhairan, Fadia S.; AlDhukair, Shahla; Ali, Mohamed M; Ali, Osman; Alkerwi, Ala'a; Alvarez-Pedrerol, Mar; Aly, Eman; Amarapurkar, Deepak N.; Amouyel, Philippe; Amuzu, Antoinette; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Andrade, Dolores S; Ängquist, Lars; Anjana, Ranjit Mohan; Aounallah-Skhiri, Hajer; Araújo, Joana; Ariansen, Inger Kristine; Aris, Tahir; Arlappa, Nimmathota; Arveiler, Dominique; Aryal, Krishna; Aspelund, Thor; Assah, Felix K.; Assunção, Maria Cecília; Aung, May Soe; Avdicová, Mária; Azevedo, Ana; Azizi, Fereidoun; Babu, Bontha V; Bahijri, Suhad; Baker, Jennifer L.; Balakrishna, Nagalla; Bamoshmoosh, Mohamed; Banach, Maciej; Bandosz, Piotr; Banegas, Jose R; Barbagallo, Carlo M.; Barcelo, Alberto; Barkat, Amina; Barros, Aluisio J.D.; Barros, Mauro V.G.; Bata, Iqbal; Biehl, Anna Månsson; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Htet, Aung Soe; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Laugsand, Lars Erik; Mathiesen, Ellisiv B.; Meisfjord, Jørgen; Meyer, Haakon E.; Sen, Abhijit; Steene-Johannessen, Jostein; Vatten, Lars Johan; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-10)
      Background: <br> Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. <br>Methods: <br> ...